Abstract #1760
Brain Templates for Neonates with Congenital Heart Defects: Preliminary Results from an International Consortium
Jue Wu 1 , Peter Schwab 2 , Arastoo Vossough 2 , James Gee 1 , and Daniel Licht 2
1
University of Pennsylvania, Philadelphia,
PA, United States,
2
Children's
Hospital of Philadelphia, PA, United States
The International Consortium on CHD Neonatal Brain MRI
was established to coordinate efforts to tackle the
problem of MR data normalization. We demonstrate the
feasibility of normalizing a set of 467 highly
heterogeneous multi-center multi-scanner MR images by
using high-deformation image registration to warp
individual images to specific templates. The
construction of specific templates based on site, age or
cardiac diagnosis allows researchers to investigate the
abnormal brain development in a more homogenous subset
and potentially increase the specificity and reliability
of the findings.
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