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Abstract #1760

Brain Templates for Neonates with Congenital Heart Defects: Preliminary Results from an International Consortium

Jue Wu 1 , Peter Schwab 2 , Arastoo Vossough 2 , James Gee 1 , and Daniel Licht 2

1 University of Pennsylvania, Philadelphia, PA, United States, 2 Children's Hospital of Philadelphia, PA, United States

The International Consortium on CHD Neonatal Brain MRI was established to coordinate efforts to tackle the problem of MR data normalization. We demonstrate the feasibility of normalizing a set of 467 highly heterogeneous multi-center multi-scanner MR images by using high-deformation image registration to warp individual images to specific templates. The construction of specific templates based on site, age or cardiac diagnosis allows researchers to investigate the abnormal brain development in a more homogenous subset and potentially increase the specificity and reliability of the findings.

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