Abstract #1769
Brain differences in toddlers at risk of ASD
Lindsay Walker 1,2 , Douglas C Dean III 2 , Jonathan OMuircheartaigh 3 , Irene Piryatinsky 2 , Nicole Waskiewicz 2 , Holly Dirks 2 , and Sean CL Deoni 2
1
Center for Biomedical Engineering, Brown
University, Providence, RI, United States,
2
Advanced
Baby Imaging Lab, Brown University, Providence, RI,
United States,
3
King's
College London, Institute of Psychiatry, London, United
Kingdom
Autism spectrum disorder (ASD) is marked by significant
behavioural, social and cognitive deficits. Early
intervention is key in allowing children with ASD to
reach their full potential, necessitating studies of
children prior to typical age of diagnosis. In this work
a small cohort of at-risk children were identified from
a longitudinal imaging study of typical brain
development. Brain myelin content was compared between
this group and an age and gender-matched group of
typically developing peers from the same study. Brain
differences were found that are consistent with a theory
of atypical brain developmental trajectories in ASD.
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