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Abstract #1769

Brain differences in toddlers at risk of ASD

Lindsay Walker 1,2 , Douglas C Dean III 2 , Jonathan OMuircheartaigh 3 , Irene Piryatinsky 2 , Nicole Waskiewicz 2 , Holly Dirks 2 , and Sean CL Deoni 2

1 Center for Biomedical Engineering, Brown University, Providence, RI, United States, 2 Advanced Baby Imaging Lab, Brown University, Providence, RI, United States, 3 King's College London, Institute of Psychiatry, London, United Kingdom

Autism spectrum disorder (ASD) is marked by significant behavioural, social and cognitive deficits. Early intervention is key in allowing children with ASD to reach their full potential, necessitating studies of children prior to typical age of diagnosis. In this work a small cohort of at-risk children were identified from a longitudinal imaging study of typical brain development. Brain myelin content was compared between this group and an age and gender-matched group of typically developing peers from the same study. Brain differences were found that are consistent with a theory of atypical brain developmental trajectories in ASD.

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