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Abstract #1770

Gradient Echo Plural Contrast Imaging in Studying Neonatal Brain Development: Preliminary Results

Jie Wen 1 , Jeffrey J. Neil 1,2 , Joseph Ackerman Jr. 1,2 , Jie Luo 3 , Terri E. Inder 2 , and Dmitriy A. Yablonskiy 1

1 Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2 Department of Pediatrics Newborn Medicine, Washington University in St. Louis, St. Louis, MO, United States, 3 Massachusetts Institute of Technology, MA, United States

Different methods have been used in the past to study brain development. Gradient Echo Plural Contrast Imaging (GEPCI) is a technique allowing generation of naturally co-registered images with various contrasts within a single MRI scan. The quantitative T2* and frequency maps derived from GEPCI show stronger contrast and more details compared with conventional clinical images. Here, we demonstrate the feasibility of applying GEPCI to evaluation of neonatal brain in health and disease. Multi-contrast GEPCI images provide multi-perspective means to explore neonatal brain development and injury quantitatively. The quantitative R2* distribution analysis shows substantial differences between term and preterm borne neonates.

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