Abstract #1774
Structural MRI measures can be affected by brain activity during image acquisition
Florian Schubert 1 , Ralf Mekle 1 , Elisabeth Wenger 2 , Nils C. Bodammer 2 , Bernd Ittermann 1 , Jrgen Gallinat 3 , and Simone Khn 2
1
Physikalisch-Technische Bundesanstalt,
Berlin, Germany,
2
Max
Planck Institute for Human Development, Berlin, Germany,
3
Charit
Universittsmedizin, Berlin, Germany
We tested the assumption that structural brain MR images
are not affected by concurrent brain function during
acquisition. MPRAGE, spin echo (TIRM) and resting state
fMRI were acquired at 3T, twice per subject, with eyes
open (EO) and closed (EC). For MPRAGE, but not for TIRM
images, voxel-based morphometry indicated larger GM
volume of bilateral visual cortex for EO vs. EC. These
regions overlapped with regions showing different
amplitudes of low-frequency fluctuation resting-state
maps for EO vs. EC. The apparent morphometric effects on
MPRAGE images may result from MPRAGEs sensitivity to
T2*. Structural images should be acquired with the
subjects eyes closed.
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