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Abstract #1774

Structural MRI measures can be affected by brain activity during image acquisition

Florian Schubert 1 , Ralf Mekle 1 , Elisabeth Wenger 2 , Nils C. Bodammer 2 , Bernd Ittermann 1 , Jrgen Gallinat 3 , and Simone Khn 2

1 Physikalisch-Technische Bundesanstalt, Berlin, Germany, 2 Max Planck Institute for Human Development, Berlin, Germany, 3 Charit Universittsmedizin, Berlin, Germany

We tested the assumption that structural brain MR images are not affected by concurrent brain function during acquisition. MPRAGE, spin echo (TIRM) and resting state fMRI were acquired at 3T, twice per subject, with eyes open (EO) and closed (EC). For MPRAGE, but not for TIRM images, voxel-based morphometry indicated larger GM volume of bilateral visual cortex for EO vs. EC. These regions overlapped with regions showing different amplitudes of low-frequency fluctuation resting-state maps for EO vs. EC. The apparent morphometric effects on MPRAGE images may result from MPRAGEs sensitivity to T2*. Structural images should be acquired with the subjects eyes closed.

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