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Abstract #1775

Weekly Scanning of a Normal Control over Four Years

Craig K Jones 1,2 , Peter A Calabresi 3 , Peter B Barker 1,2 , and Peter CM van Zijl 1,2

1 Dept of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 3 Dept of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Numerous studies report on serial scans over short periods of time or infrequent scans over a long period of time but there are no published accounts of frequent serial scanning for a long term. Here, MPRAGE, dual-echo-T2, FLAIR, DTI and magnetization-transfer-weighted scans were acquired weekly in a normal control for four years. White matter, gray matter, cortical gray matter and CSF volumes were calculated. This data will be useful to validate the use of these sequences for tracking changes in signal intensity and brain volumes over time in patient groups with subtle neurological disorders and for treatment response.

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