Abstract #1792
Pediatric ALL: Characterization of WM Damage and Associated Risk Factors
Jennifer R. Pryweller 1 , John O. Glass 1 , Xingyu Li 2 , Yimei Li 2 , and Wilburn E. Reddick 1
1
Department of Radiological Sciences, St.
Jude Children's Research Hospital, Memphis, TN, United
States,
2
Department
of Biostatistics, St. Jude Children's Research Hospital,
Memphis, TN, United States
MR neuroimaging studies of pediatric acute lymphoblastic
leukemia (ALL), the most common form of pediatric
cancer, reveal leukoencenphalopathy (LE), the most
common neurotoxic side effect of treatment with high
dose methotrexate. Because neurocognitive deficits
resulting from LE in pediatric ALL patients can have
devastating effects on quality of life, long term, the
purpose of our study was to objectively assess influence
and risk factors for LE in these, which was
characterized by T1 and T2 intensity and relaxation
rates, and the volumetric extent of abnormal white
matter.
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