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Abstract #1795

Validation of Cortical Thickness/Volume Data from Multi-Echo MPRAGE Scans with Variable Acceleration in Young and Elderly Populations

Ross W. Mair 1,2 , Martin Reuter 2,3 , and Andre J. van der Kouwe 2

1 Center for Brain Science, Harvard University, Cambridge, MA, United States, 2 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States, 3 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

The multi-echo MPRAGE (MEMPRAGE) sequence was implemented to reduce signal distortion by acquiring at a higher bandwidth and averaging multiple echoes to recover SNR while providing additional T2* information that can enhance cortical segmentation. Here, we compare morphometric results for cortical thickness/gray matter volume obtained from a rapid 2-minute MEMPRAGE scan with four-fold acceleration by comparison to those from a 6-minute, 1 mm isotropic, two-fold accelerated MEMPRAGE scan acquired in the same session. The results show a small but usually significant bias to the p2 scan, but correlations remain high. Good correlation is also obtained for morphometric data between scans on elderly subjects, albeit with slightly lower correlation than for healthy young adults.

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