Abstract #1795
Validation of Cortical Thickness/Volume Data from Multi-Echo MPRAGE Scans with Variable Acceleration in Young and Elderly Populations
Ross W. Mair 1,2 , Martin Reuter 2,3 , and Andre J. van der Kouwe 2
1
Center for Brain Science, Harvard
University, Cambridge, MA, United States,
2
Athinoula
A. Martinos Center for Biomedical Imaging, Department of
Radiology, Harvard Medical School, Massachusetts General
Hospital, Charlestown, MA, United States,
3
Department
of Mechanical Engineering, Massachusetts Institute of
Technology, Cambridge, Massachusetts, United States
The multi-echo MPRAGE (MEMPRAGE) sequence was
implemented to reduce signal distortion by acquiring at
a higher bandwidth and averaging multiple echoes to
recover SNR while providing additional T2* information
that can enhance cortical segmentation. Here, we compare
morphometric results for cortical thickness/gray matter
volume obtained from a rapid 2-minute MEMPRAGE scan with
four-fold acceleration by comparison to those from a
6-minute, 1 mm isotropic, two-fold accelerated MEMPRAGE
scan acquired in the same session. The results show a
small but usually significant bias to the p2 scan, but
correlations remain high. Good correlation is also
obtained for morphometric data between scans on elderly
subjects, albeit with slightly lower correlation than
for healthy young adults.
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