Glutamate Concentration is Directly Correlated with Alpha Power Attenuation from Eyes Closed to Eyes Open in Human Occipital Lobe

One classically observed EEG signal is the attenuation in power in the alpha bandwidth (8-12 Hz) that is seen when a subject goes from resting with eyes closed to resting with eyes open. The neurochemical contributions to this phenomenon are not clearly understood, however it is believed that the activation and resultant desynchronization of glutamatergic pyramidal neurons are the underlying cause. In this study, magnetic resonance spectroscopy was used to determine the impact that glutamate concentration in the occipital lobe may have on an individuals alpha attenuation. As predicted, glutamate concentration and alpha attenuation are significantly and directly related.

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