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Abstract #1806

Metabolite concentration changes in the human auditory cortex using functional Magnetic Resonance Spectroscopy (fMRS) at 7 Tesla

Benoit Schaller 1 , Lijing Xin 2 , and Rolf Gruetter 1

1 Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland, 2 Department of Radiology, University of Lausanne, Lausanne, Vaud, Switzerland

Functional MRS investigates metabolite changes during neuronal activation by continuously acquiring MR spectra during a functional task. Recent fMRS studies performed at 7 T reported similar metabolite changes, in particular a lactate increase around 10-20% during visual and motor activation. Thus, it is of interest to further characterize the relationship between neuronal activation and energy metabolism, in other brain areas, such as the auditory cortex in the human brain investigated here for the first time. Statistically significant increases of Lac by 114% (p<0.02, n=7) and of Glu by 21% (p<0.007, n=7) were found. We suggest that Glu and Lac changes may be a general manifestation of neuronal activation.

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