Abstract #1821
Differences in Cerebrovascular Reactivity in Posterior Circulation Territories obtained with BOLD and ASL MRI using Hypercapnic Challenges
Jeroen C.W. Siero 1 , Alex Bhogal 1 , Carlos Faraco 2 , Jeroen Hendrikse 1 , and Manus J. Donahue 2
1
University Medical Center Utrecht, Utrecht,
Utrecht, Netherlands,
2
Radiology
and Radiological Sciences, Vanderbilt University, TN,
United States
We performed cerebrovascular reactivity measurements in
healthy subjects using BOLD and CBF for different
hypercapnic and hyperoxic conditions, focussing on
posterior circulation territories. Results demonstrate
that CVR in posterior circulation territories is
regionally dependent, at least for CBF. Observed
differences between CBF and BOLD based CVR may indicate
differences in vascular and metabolic condition. Future
work will aim at elucidating and separating these
effects by comparing healthy subjects and patients with
posterior circulation pathology.
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