Abstract #1822
Investigating BOLD signal properties under targeted hyperoxic combined with progressive hypercapnia at 7T
Alex Bhogal 1 , Esben Petersen 1 , Manus J Donahue 2 , Marielle Philippens 3 , Peter Luijten 1 , Hans Hoogduin 1 , and Jeroen C.W. Siero 1
1
Radiology, University Medical Center,
Utrecht, Netherlands,
2
Radiology
and Radiological Sciences, Vanderbilt University, TN,
United States,
3
Radiotherapy,
University Medical Center, Utrecht, Netherlands
Using high spatio and temporal resolution BOLD imaging
at 7T in combination with a prospective end-tidal gas
targeting system (RespirAct), we examine the
non-linearity of the BOLD-CVR response to increasing
PaCO2 under targeted normoxia and hyperoxia in order to
shed light on vascular (maximum vasodilation) and
susceptibility dependent (BOLD ceiling) BOLD signal
components.
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