Abstract #1839
White matter hyperintensities as a confounder in diffusion tensor imaging analysis of elderly cohorts
Daniel Svrd 1 , Filip Szczepankiewicz 2 , Markus Nilsson 3 , Bjrn Lampinen 2 , Jimmy Ltt 4 , Pia Sundgren 1,4 , Erik Stomrud 5 , Lennart Minthon 5 , Katarina Ngga 5 , Oskar Hansson 5 , and Danielle van Westen 1,4
1
Diagnostic Radiology, Department of Clinical
Sciences Lund, Lund University, Lund, Sweden,
2
Department
of Medical Radiation Physics, Lund University, Lund,
Sweden,
3
Lund
University Bioimaging Center, Lund University, Lund,
Sweden,
4
Center
for Medical Imaging and Physiology, Skne University
Hospital, Lund, Sweden,
5
Clinical
Memory Research Unit, Department of Clinical Sciences
Malm, Lund University, Malm, Sweden
Studies on the effect of white matter hyperintensities (WMH),
appearing on T2-weighted images, on diffusion tensor
imaging (DTI) parameters are scarce in spite of their
abundance in normal aging as well as in
neurodegenerative disease. Here we quantify the effect
size of WMH graded according to Fazekas on DTI
parameters mean diffusivity and fractional anisotropy in
a healthy elderly cohort using ROI-based analysis. We
show that WMH have effect sizes comparable to that of
some neurodegenerative diseases and therefore may be an
important factor taken into consideration when designing
DTI studies including groups with different WMH load.
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