Abstract #1840
Is the rate of change in fractional anisotropy with age constant within white matter tracts? A study of two segments of the Cingulum bundle
Johanna Mrtensson 1 , Jimmy Ltt 2 , Danielle van Westen 3 , Elna-Marie Larsson 1 , and Markus Nilsson 4
1
Radiology, Radiology, Oncology and Radiation
Science, Uppsala, Uppsala, Sweden,
2
Center
for Medical Imaging and Physiology, Skne University
Hospital, Lund, Lund, Sweden,
3
Diagnostic
Radiology, Skne University Hospital, Lund, Lund,
Sweden,
4
Lund
University Bioimaging Center, Lund University, Lund,
Lund, Sweden
We divide cingulum into two segments and examine the
patterns of age-related WM changes in fractional
anisotropy (FA) within the segments. The purpose is to
investigate whether an antero-posterior gradient in the
rate of ageing is present. DTI-MRI was performed on 80
volunteers and FA within the segments analysed as
functions of age. FA in the anterior segment decreased
18% between the age of 30 and 83, while FA in the
posterior segment decreased 8.3%. Differences in
age-related changes may be partly explained by the
retrogenesis hypothesis in case cingulum is composed of
separate tracts and agrees with antero-posterior
maturation.
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