Abstract #1844
Prediction of progression free survival in high grade gliomas using pre-operative MR
Lawrence Kenning 1 , Martin Lowry 2 , Martin Pickles 2 , Christopher Roland-Hill 3 , Shailendra Achawal 3 , Chittoor Rajaraman 3 , and Lindsay W Turnbull 2,3
1
Centre for Magnetic Resonance
Investigations, University of Hull, Hull, East Riding of
Yorkshire, United Kingdom,
2
Centre
for Magnetic Resonance Investigations, Hull York Medical
School at the University of Hull, Hull, East Riding of
Yorkshire, United Kingdom,
3
Hull
and East Yorkshire Hospitals NHS Trust, East Riding of
Yorkshire, United Kingdom
We investigated whether MR could predict progression
free survival at 6 months in high grade gliomas. DTI,
DCE and DSC were acquired from 39 patients. Volumes of
interest were contoured before patients were
dichotomised using median values for each parameter.
Kaplan-Meier survival analysis at 210 days from
pre-operative MR was calculated along with log rank
tests to test for significance. Individually, ADC, q, λR,
Ktrans, Ve, Vb, and K2 were all significant predictors
of progression free survival. Pre-operative MR
parameters can predict progression free survival at 6
months in high grade gliomas. DTI, DSC and DCE all have
added value.
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