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Abstract #1844

Prediction of progression free survival in high grade gliomas using pre-operative MR

Lawrence Kenning 1 , Martin Lowry 2 , Martin Pickles 2 , Christopher Roland-Hill 3 , Shailendra Achawal 3 , Chittoor Rajaraman 3 , and Lindsay W Turnbull 2,3

1 Centre for Magnetic Resonance Investigations, University of Hull, Hull, East Riding of Yorkshire, United Kingdom, 2 Centre for Magnetic Resonance Investigations, Hull York Medical School at the University of Hull, Hull, East Riding of Yorkshire, United Kingdom, 3 Hull and East Yorkshire Hospitals NHS Trust, East Riding of Yorkshire, United Kingdom

We investigated whether MR could predict progression free survival at 6 months in high grade gliomas. DTI, DCE and DSC were acquired from 39 patients. Volumes of interest were contoured before patients were dichotomised using median values for each parameter. Kaplan-Meier survival analysis at 210 days from pre-operative MR was calculated along with log rank tests to test for significance. Individually, ADC, q, λR, Ktrans, Ve, Vb, and K2 were all significant predictors of progression free survival. Pre-operative MR parameters can predict progression free survival at 6 months in high grade gliomas. DTI, DSC and DCE all have added value.

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