Comparison of Quantitative Heterogeneity of Brain Tumors from Diffusion MR Versus Histological Tumour Grade: A Preliminary Study

In this study, heterogeneity of brain tumors from Apparent Diffusion Co-efficient (ADC) maps is compared with histological tumour grade. 1.5T MR data from 10 patients with brain tumour was retrospectively analyzed. Based on modified co-occurrence matrix based method, a heterogeneity index was computed, which was then compared with the final histological tumour grade after surgical resection. Heterogeneity index (from ADC maps) could discriminate between grade 4 and lower grade tumours. For lower grade tumours, small sample size precluded comparative analysis between tumour grade and heterogeneity index. Tumour heterogeneity could be a better marker for tumour grade than mean ADC values.

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