Abstract #1854
Differential diagnosis of brain tumor recurrence and radiation necrosis using MR spectroscopy
Dita Wagnerova 1 , Alberto Malucelli 2 , Monika Dezortova 1 , Filip Jiru 1 , Antonin Skoch 1 , Robert Bartos 2 , Martin Sames 2 , and Milan Hajek 1
1
Department of Diagnostic and Interventional
Radiology, Institute for Clinical and Experimental
Medicine, Prague, Czech Republic,
2
Department
of Neurosurgery, JE Purkyne University and Masaryk
Hospital, Usti nad Labem, Czech Republic
MR imaging and MR spectroscopy are used for a
differential diagnosis (DD) between tumor recurrence and
radionecrosis. In case of MR spectroscopy, most of the
authors recommend using increased Choline to Creatine
ratio (Cho/Cr) as a marker of tumor recurrence. To
further explore this issue, we compared several MRS
evaluation methods with histopathology. We found
statistically different Cho/Cr values between group of
tumor recurrence and group of radionecrosis. However,
case-by-case specificity was low. As tumor recurrence
showed interhemispheral Choline increase > 15% and
radionecrosis < 15%, interhemispheral comparison of
Choline values in individual subjects was the best
method for DD.
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