Histogram Analysis of Saturation Time Dependent Amide Proton Transfer MRI in Brain Metastases

In recent years, amide proton transfer (APT) MRI techniques based on endogenous contrast of exchangeable amide protons of intra-cellular proteins and peptides have been developed successfully and applied in initial clinical studies for oncology and neurology applications. For analysis of the obtained APT measures in tumor tissue and contralateral normal appearing white matter (NAWM), ROI averages are typically used. Because the tumor tissue is often very heterogeneous, histogram analyses and multi-compartment fits are applied in this study on human brain metastases (N=5). Different durations of the sensitizing RF saturation pulse were chosen. With increasing duration, multiple compartments are clearly observed while the overall tumor to NAWM contrast is enhancing. Histogram type analysis is strongly recommended for further investigation of APT contrasts in tumor tissue characterization.

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