Meeting Banner
Abstract #1856

Serial and 2 TE-Acquisition 23 Na MRI for Assessment of Therapy Response in Pediatric Glioma

Vincent Kyu Lee 1 , Yongxian Qian 1,2 , Fernando Boada 3 , James Mountz 1 , and Ashok Panigrahy 1

1 Radiology, University of Pittsburgh, Pittsburgh, Pa, United States, 2 Bioengineering, University of Pittsburgh, Pa, United States, 3 Radiology, New York University, NY, United States

In this study, we used serial single quantum 23 Na imaging at two separate echo times to study pediatric astrocytomas (total n=8 patients) to help distinguish between proliferation and therapy response. The protein bound sodium, predominantly associated with intracellular sodium, was obtained by subtraction of free sodium (long echo) from total sodium (ultrashort echo). Using this serial 2 TE-Acquisition technique, we were able to characterize the differences in relative sodium concentration between tumors progressing and those lesions responding to therapy. This methodology may prove valuable in assessment of molecularly targetedbased innovative treatment for differentiating pseudoprogression or heterogeneous treatment response.

This abstract and the presentation materials are available to members only; a login is required.

Join Here