Abstract #1857
Non-invasive MR oxygen mapping of primary central nervous system tumors
Marta M Safronova 1 , Florence Colliez 2 , Julie Magat 2 , Bndicte F Jordan 2 , Bernard Gallez 2 , and Thierry Duprez 3
1
Service de Radiologie, Cliniques
universitaires Saint-Luc, Brussels, Belgium,
2
Louvain
Drug Research Institute, Biomedical Magnetic Resonance
Research Group, University of Louvain, Brussels,
Belgium,
3
Department
of Radiology and Medical Imaging, Cliniques
universitaires Saint-Luc, Brussels, Belgium
Neuroepithelial tumors are the most frequent primary
central nervous system tumors. Non-invasive measurements
of tissue oxygen level variations can be obtained using
oxygen itself as an endogenous paramagnetic contrast, a
method coined Oxygen enhanced MRI providing T1
measurements influenced by O2-related relaxation of
water protons. Based on higher solubility of oxygen in
lipids than in water, a more sensitive method was
developed: MOBILE (Mapping of Oxygen By Imaging Lipids
relaxation Enhancement). The aim of this study was to
assess the clinical applicability of MOBILE for mapping
oxygenation of primary central nervous system tumors.
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