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Abstract #1857

Non-invasive MR oxygen mapping of primary central nervous system tumors

Marta M Safronova 1 , Florence Colliez 2 , Julie Magat 2 , Bndicte F Jordan 2 , Bernard Gallez 2 , and Thierry Duprez 3

1 Service de Radiologie, Cliniques universitaires Saint-Luc, Brussels, Belgium, 2 Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium, 3 Department of Radiology and Medical Imaging, Cliniques universitaires Saint-Luc, Brussels, Belgium

Neuroepithelial tumors are the most frequent primary central nervous system tumors. Non-invasive measurements of tissue oxygen level variations can be obtained using oxygen itself as an endogenous paramagnetic contrast, a method coined Oxygen enhanced MRI providing T1 measurements influenced by O2-related relaxation of water protons. Based on higher solubility of oxygen in lipids than in water, a more sensitive method was developed: MOBILE (Mapping of Oxygen By Imaging Lipids relaxation Enhancement). The aim of this study was to assess the clinical applicability of MOBILE for mapping oxygenation of primary central nervous system tumors.

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