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Abstract #1863

Evaluation of parametric response map (PRM) as an imaging biomarker in the study of a cell therapy in stroke

Rui He 1,2 , Benjamin Lemasson 1,2 , Anack Moisan 1,2 , Olivier Detante 2,3 , Chantal Rmy 1,2 , Alexandre Krainik 2,3 , and Emmanuel Luc Barbier 1,2

1 U836, Inserm, Grenoble, France, 2 Grenoble Institut des Neurosciences, University Grenoble 1, Grenoble, France, 3 Grenoble University Hospital, Grenoble, France

Twenty rats underwent stroke (transient middle cerebral artery occlusion, MCAo) and 12 sham surgery. At Day8, MCAo rats received an intravenous injection of either cell suspension medium (n=10) or of human mesenchymal stem cells (hMSCs, n=10). ADC was mapped at 7T from Day3 to Day16. ADC changes were assessed by parametric response map (PRM), a voxel-based analysis. PRM showed that the fraction of the lesion with decreased ADC was significantly higher in MCAo-PBS than MCAo-hMSC at Day9, suggesting that hMSCs decreased the post-ischemic cellular edema. This difference revealed by PRM, was masked by mean-value comparisons.

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