Abstract #1863
Evaluation of parametric response map (PRM) as an imaging biomarker in the study of a cell therapy in stroke
Rui He 1,2 , Benjamin Lemasson 1,2 , Anack Moisan 1,2 , Olivier Detante 2,3 , Chantal Rmy 1,2 , Alexandre Krainik 2,3 , and Emmanuel Luc Barbier 1,2
1
U836, Inserm, Grenoble, France,
2
Grenoble
Institut des Neurosciences, University Grenoble 1,
Grenoble, France,
3
Grenoble
University Hospital, Grenoble, France
Twenty rats underwent stroke (transient middle cerebral
artery occlusion, MCAo) and 12 sham surgery. At Day8,
MCAo rats received an intravenous injection of either
cell suspension medium (n=10) or of human mesenchymal
stem cells (hMSCs, n=10). ADC was mapped at 7T from Day3
to Day16. ADC changes were assessed by parametric
response map (PRM), a voxel-based analysis. PRM showed
that the fraction of the lesion with decreased ADC was
significantly higher in MCAo-PBS than MCAo-hMSC at Day9,
suggesting that hMSCs decreased the post-ischemic
cellular edema. This difference revealed by PRM, was
masked by mean-value comparisons.
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