Time-to-Peak of T 2 *-Weighted Signal Change of Oxygen Challenge as a Biomarker of Penumbra
Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q Duong 1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States
Percent change of T2*-weighted signal following oxygen
challenge (OC) has been used as a biomarker of penumbra.
However, T2*-weighted MRI of OC challenge in delineating
tissue at risk has low contrast-to-noise sensitivity and
there are significant false positive and negative
pixels, particular from pixels that contain large
vessels. In order for this biomarker to be practical, it
is necessary to improve its specificity and sensitivity.
The goal of this study was to explore the use of the
time-to-peak of OC response to further improve the
identification of at-risk tissue in ischemic stroke.
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