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Abstract #1866

Asymmetric magnetization transfer effects for perfusion imaging in transient ischemic brain tissue in rats

Kazuhiro Nakamura 1 , Junko Kawamura 1 , Yasushi Kondoh 1 , Hajime Miyata 1 , and Toshibumi Kinoshita 1

1 Akita Research Institute for Brain and Blood Vessels, Akita, Akita, Japan

Several studies show post-ischemic hyperperfusion at 48 hours after reperfusion in the transient ischemic tissue using continuous arterial spin labeling (CASL) method. Asymmetric magnetization transfer (MT) effects have not been investigated in these studies. In our experiments, cerebral blood flow (CBF) using CASL method (CASL CBF) with minus polarities of the labeling gradient was higher than that with plus polarities. The results showing asymmetric MT effect in CASL CBF must be compensated even though the two-coil system. After compensation of the MT effect, CASL CBF at 48 hours after reperfusion was still significantly higher than at 24 and 72 hours.

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