Abstract #1867
Combination normobaric oxygen and methylene blue treatment delays the progression of ischemic penumbra into infarct and promotes behavioral recovery
Pavel Rodriguez 1,2 , Jiang Zhao 2 , Brian Milman 3 , Lora Talley Watts 2 , and Timothy Q. Duong 2
1
Department of Radiology, University of Texas
Health Science Center at San Antonio, San Antonio,
Texas, United States,
2
Research
Imaging Institute, University of Texas Health Science
Center at San Antonio, San Antonio, Texas, United
States,
3
School
of Medicine, University of Texas Health Science Center
at San Antonio, Texas, United States
We previously reported that methylene blue (MB) an
energy enhancing and antioxidant reduces infarct
volume in 60-mins and permanent MCAO in rats. This study
investigated the combination therapy of MB and
normobaric oxygen (NBO) treatment in ischemic stroke. We
hypothesized that MB+NBO treatment delays infarct growth
and salvages more tissue than NBO + Vehicle treatment
alone in a 60-min MCAO model in rats and that
longitudinal MB treatment promotes faster motor
functional behavioral recovery.
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