Abstract #1868
Evolution of Fractional Anisotrophic Changes In An Animal Model of Ischemic Stroke: Relative Contribution of Anisotropic Versus Magnitude Diffusivity
Cheng-Yu Chen 1,2 , Duen-Pang Kuo 3,4 , Hsiao-Wen Chung 4 , Chen Chang 5 , and Ping-Huei Tsai 1
1
Department of Medical Imaging and Imaging
Research Center, Taipei Medical University Hospital,
Taipei Medical University, Taipei, Taiwan,
2
Graduate
Institue of Clinical Medicine, Taipei Medical
University, Taipei, Taiwan,
3
Department
of Radiology, Taoyuan Armed Forces General Hospital,
Taoyuan, Taiwan,
4
Graduate
Institute of Biomedical Electrics and Bioinformatics,
National Taiwan University, Taipei, Taiwan,
5
Functional
and Micro-magnetic Resonance Imaging Center, Academic
Sinica, Taipei, Taiwan
Although FA is one of the most common indices used in
diffusion tensor imaging reflecting the brain
microstructural changes, the FA changes in acute
ischemic stroke may not be specific due to two
components, q and L, included. Therefore, the aim of our
study is to investigate the differential behaviors of q
and L in the ischemic penumbra versus the infarct core
using a longitudinal rat stroke model. Our preliminary
result suggests that q may detect stroke-related
abnormality with a higher sensitively than L, and the
relative stable q in ischemic penumbra may provide
insight into the definition of salvageable brain tissue
in hypoperfused brain at acute setting.
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