Abstract #1869
Longitudinal microstructural white matter changes in a transient focal ischemic stroke rat model using a tract-based spatial statistics (TBSS) method
Won Beom Jung 1 , Jae Hun Kim 2 , Geun Ho Im 1 , Moon Sun Jang 1 , Kyoung Nam Kim 1 , Julius Juhyun Chung 3 , Sun Young Chae 3 , and Jung Hee Lee 1,2
1
Center for Molecular and Cellular Imaging,
Samsung Biomedical Research Institute, Samsung Medical
Center, Seoul, Korea,
2
Department
of Radiology, Samsung Medical Center, Sungkyunkwan
University School of Medicine, Seoul, Korea,
3
Samsung
Advanced Institute for Health Sciences & Technology,
Sungkyunkwan University, Seoul, Korea
In this study, we examined the microstructural white
matter changes after ischemia in rats over time from
acute (4 hours) and sub-acute (1 week) to chronic (3 and
6 weeks) stages using tract-based spatial statistics (TBSS)
method. The frectional anisotropy (FA) values decreased
in perilesional white matter tracks at sub-acute stage
and gradually normalized from corpus callosum to
external capsule at later stages. In addition, the mean
diffusivity (MD) values decreased at acute stage and
dramatically increased at later stages. We believe that
the longitudinal FA changes ranging from decrease to
normalization may reflect the recovery of ischemic brain
damage by WM restoration.
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