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Abstract #1870

Can Cortical Spreading Depolarization Serve as a Marker for Tissue Plasminogen Activator (tPA) Toxicity for Stroke Treatment?

Yu-Chieh Jill Kao 1 , Wenjing Li 1 , Weili Lin 1,2 , and Yen-Yu Ian Shih 1

1 Experimental Neuroimaging Laboraory, Department of Neurology and BRIC, University of North Carolina, Chapel Hill, North Carolina, United States, 2 Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, United States

In this study, we aimed to demonstrate that: (i) controllable ischemic lesions can be generated in our model inside the MRI, and (ii) tPA will attenuate PIDs in mild ischemic injury and exacerbate PIDs in more severe injury.

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