Can Cortical Spreading Depolarization Serve as a Marker for Tissue Plasminogen Activator (tPA) Toxicity for Stroke Treatment?
Yu-Chieh Jill Kao 1 , Wenjing Li 1 , Weili Lin 1,2 , and Yen-Yu Ian Shih 1
Experimental Neuroimaging Laboraory,
Department of Neurology and BRIC, University of North
Carolina, Chapel Hill, North Carolina, United States,
of Biomedical Engineering, University of North Carolina,
Chapel Hill, NC, United States
In this study, we aimed to demonstrate that: (i)
controllable ischemic lesions can be generated in our
model inside the MRI, and (ii) tPA will attenuate PIDs
in mild ischemic injury and exacerbate PIDs in more
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