Abstract #1870
Can Cortical Spreading Depolarization Serve as a Marker for Tissue Plasminogen Activator (tPA) Toxicity for Stroke Treatment?
Yu-Chieh Jill Kao 1 , Wenjing Li 1 , Weili Lin 1,2 , and Yen-Yu Ian Shih 1
1
Experimental Neuroimaging Laboraory,
Department of Neurology and BRIC, University of North
Carolina, Chapel Hill, North Carolina, United States,
2
Department
of Biomedical Engineering, University of North Carolina,
Chapel Hill, NC, United States
In this study, we aimed to demonstrate that: (i)
controllable ischemic lesions can be generated in our
model inside the MRI, and (ii) tPA will attenuate PIDs
in mild ischemic injury and exacerbate PIDs in more
severe injury.
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