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Abstract #1871

Effects of Residual Oxygen Molecule on BOLD signal: MRI Study Using Spontaneously Breathing Brain Stroke model

Ji-Yeon Suh 1 , YoungKyu Song 1 , Jeong Kon Kim 1,2 , Young Ro Kim 3 , and Gyunggoo Cho 1

1 Magnetic Resonance Research, Korea Basic Science Institute, Cheongwon, Chungbuk, Korea, 2 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, 3 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, United States

BOLD signal has been accepted to have both signal changes, positive change by the deoxyHb decrease as well as negative change by oxygen paramagnetism. In this study, in order to evaluate the role of oxygen, the relaxation times and the MRI-derived blood volumes were measured with 21% and 100% O2 gas inhalations in ischemic rat brains. Our results demonstrated the excessive oxygen molecules remained in the stroke-affected tissues by the lack of oxygen metabolism have different actions in terms of R1 and blood volume changes, indicating that different levels of oxygen molecules may be related to the different changes of BOLD signals.

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