Towards clinical implementation of IVIM analysis in brain tumors: Influence of cerebrospinal fluid contamination on the perfusion fraction

The dependence of perfusion fraction (f) on CSF in IVIM analysis of brain can be demonstrated by DWI measurements with 2 different TEs. The f in cortical or juxta-cortical regions was higher in measurements with longer TE indicating that the fast decaying signal component had long T2, as expected for CSF. In white matter and tumor tissue, f showed no dependence on TE. Considering the influence of CSF on f values and the robustness of the method in lesions located in white matter and tumors is very important prior to any clinical dissemination of IVIM analysis in brain pathologies.

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