Abstract #1889
System imbalance of activated external awareness yet deactivated internal awareness in the vegetative state detected by resting state fMRI
Jianghong He 1 , Yi Zhang 1,2 , Zhenyu Zhou 3 , Ruxiang Xu 1 , and Yijun Liu 4
1
Department of Neurosurgery, Beijing Army
General Hospital, Beijing 100700, China,
2
School
of Life Science and Technology, Xidian University,
Xi'an, Shanxi 710071, China,
3
GE
Healthcare, Beijing 100176, China,
4
Department
of Biomedical Engineering, Peking University, Beijing
100871, China
People's Republic of In disorders of consciousness
(DOC), the vegetative state (VS) represents a unique
mental status distinct from coma and the minimally
conscious state. Functional MRI (fMRI) reveals that
awareness can be reduced to two coexistent networks---
the external and internal awareness, and that the two
components are anti-correlates. According to this
framework, the present study hypothesizes that there is
imbalance between the external and internal awareness in
VS. Our study provides evidence that VS in DOC patients
is likely related to the imbalance between the external
and internal awareness systems as well as the DMN. The
hyperactivaion of external awareness system and the
hypoactive internal awareness and DMN exhibit a key
pattern of brain activity in the unique mental states of
VS, which may be further characterized as prognostic
markers of VS and DOC.
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