Abstract #1888
Failure of connectivity modulation during an attentional task in children with epilepsy is not explained fully by interictal activity
Elhum Shamshiri 1 , Maria Centeno 1 , Kelly St Pier 2 , Suejen Perani 1 , Helen Cross 3 , and David Carmichael 1
1
UCL Institute of Child Health, London, UK,
United Kingdom,
2
Epilepsy
Unit, Great Ormond Street Hospital, London, UK, United
Kingdom,
3
Neurosciences
Unit, UCL Institute of Child Health, London, UK, United
Kingdom
The current study looks at aberrant cognitive networks
previously established in children with epilepsy by
exploring the task-related differences between patients
and controls during a natural stimulus and resting
state. We used a GLM in SPM8 as well as functional
connectivity looking at temporal changes in BOLD
response to analyse the results. Significant differences
between groups are found in the dorsal anterior
cingulate cortex. Additionally, connectivity results
showed that patients recruit more brain regions than
controls in performing cognitive tasks, and that
patients are also shown to have problems with task
switching and cognitive network modulation when compared
to controls.
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