Abstract #1887
Impact of Hypertension and Aging on Resting State BOLD Response to Heart Rate Variation
Wendy W Ni 1 , Catie Chang 2 , Hesamoddin Jahanian 3 , Gary H Glover 3 , and Greg Zaharchuk 3
1
Department of Electrical Engineering,
Stanford University, Stanford, CA, United States,
2
Advanced
MRI Section, LFMI, NINDS, NIH, Bethesda, MD, United
States,
3
Department
of Radiology, Stanford University, Stanford, CA, United
States
Cardiac contribution to resting state BOLD signal
fluctuations may be modeled as a linear response to
heart rate variation using the RVHR model. In this
study, we interpret three features of the response
function as indicators of the strength of
cerebrovascular autoregulation, and examine the
differences between young normals, elderly subjects with
hypertension and chronic kidney disease, and elderly
normals. We find statistically significant differences
in response strength between young and elderly normals,
and between elderly normals and patients. Our numerical
results also suggest that aging reduces autoregulation,
while hypertension obscures the effect of aging on BOLD
signal fluctuations.
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