Abstract #1886
The Effect of Hypoxia on Cerebral Arterial Calibre and Flow Velocity - An MRI Study
Ravjit Singh Sagoo 1 , David Bailey 1 , Sarah Wayte 2 , Eddie Ng'andwe 1 , Charles Handford 3 , Sanjoy Nagaraja 1 , Mahmud Saedon 4 , Helen Parsons 5 , Alex Wright 6,7 , Arthur Bradwell 6,7 , Christopher Imray 4,7 , and Charles Hutchinson 1,8
1
Department of Imaging, University Hospitals
Coventry and Warwickshire NHS Trust, Coventry, West
Midlands, United Kingdom,
2
Department
of Medical Physics, University Hospitals Coventry and
Warwickshire NHS Trust, Coventry, West Midlands, United
Kingdom,
3
University
Hospitals Birmingham NHS Foundation Trust, Birmingham,
United Kingdom,
4
Department
of Surgery, University Hospitals Coventry and
Warwickshire NHS Trust, Coventry, West Midlands, United
Kingdom,
5
Division
of Health Sciences, Warwick Medical School, University
of Warwick, Coventry, West Midlands, United Kingdom,
6
University
of Birmingham, Birmingham, United Kingdom,
7
Birmingham
Medical Research Expeditionary Society, Birmingham,
United Kingdom,
8
University
of Warwick, Coventry, West Midlands, United Kingdom
One of the processes responsible for maintaining oxygen
delivery in high altitude climbers is an increase in
cerebral arterial flow velocity. Arterial dilatation has
long thought to play no part in maintaining cerebral
oxygenation, a theory that has recently been disputed.
This study documents changes in middle cerebral artery
(MCA) calibre, flow velocity, flow and calculated oxygen
delivery in response to a 22-hour period of normobaric
hypoxia in 12 subjects. MCA flow velocity significantly
increased to maintain cerebral oxygen (p<0.05) while the
increase in MCA calibre approached significance
(p=0.09). A larger number of subjects may be needed to
detect significance.
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