Abstract #1891
Connectivity increase in reward-related brain regions in patients with congenital lipodystrophy: A longitudinal study with leptin-substitution treatment
Haiko Schlgl 1,2 , Karsten Mueller 1 , Annette Horstmann 1,3 , Harald E Mller 1 , Konstanze Miehle 2 , Burkhard Pleger 1,4 , Arno Villringer 1,4 , Mathias Fasshauer 2,3 , and Michael Stumvoll 2,3
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
2
Department
for Internal Medicine, University Hospital Leipzig,
Germany,
3
Integrated
Research and Treatment Center (IFB) Adiposity Diseases,
Leipzig, Germany,
4
Day
Clinic for Cognitive Neurology, University Hospital
Leipzig, Germany
Patients with congenital lipodystrophy (LD) present
reduced serum leptin concentrations, leading to
disturbed eating behavior with the inability to develop
sustaining satiety. We substituted leptin in eight LD
patients and assessed functional resting state MRI
during the first year of the treatment. Leptin
substitution lead to decreased hunger and increased
post-meal satiety. In fMRI we found a strengthened
functional connectivity in dopaminergic reward regions
(nucleus accumbens and medial prefrontal cortex) as well
as the hedonic control centre (hypothalamus). These data
suggest long-term adaptation of the interconnectedness
of brain areas involved in the control eating behavior
after leptin substitution in LD.
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