Meeting Banner
Abstract #1891

Connectivity increase in reward-related brain regions in patients with congenital lipodystrophy: A longitudinal study with leptin-substitution treatment

Haiko Schlgl 1,2 , Karsten Mueller 1 , Annette Horstmann 1,3 , Harald E Mller 1 , Konstanze Miehle 2 , Burkhard Pleger 1,4 , Arno Villringer 1,4 , Mathias Fasshauer 2,3 , and Michael Stumvoll 2,3

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Department for Internal Medicine, University Hospital Leipzig, Germany, 3 Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig, Germany, 4 Day Clinic for Cognitive Neurology, University Hospital Leipzig, Germany

Patients with congenital lipodystrophy (LD) present reduced serum leptin concentrations, leading to disturbed eating behavior with the inability to develop sustaining satiety. We substituted leptin in eight LD patients and assessed functional resting state MRI during the first year of the treatment. Leptin substitution lead to decreased hunger and increased post-meal satiety. In fMRI we found a strengthened functional connectivity in dopaminergic reward regions (nucleus accumbens and medial prefrontal cortex) as well as the hedonic control centre (hypothalamus). These data suggest long-term adaptation of the interconnectedness of brain areas involved in the control eating behavior after leptin substitution in LD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here