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Abstract #1892

Preliminary study on structural brain network topology in chronic knee OA pain

Yue Xing 1,2 , Hamza Alshuft 1,2 , and Dorothee Auer 1,2

1 Radiological Sciences, University of Nottingham, Nottingham, United Kingdom, 2 Arthritis Research UK Pain Centre, University of Nottingham, Nottinghamshire, United Kingdom

Graph theory combining MRI techniques enables a non-invasive description of structural and functional network topology in human brain. Despite the recent explosion of studies on functional brain network and anatomical connectivity provided by diffusion MRI, little is known about the structural architecture in patients with primary nociceptive disorders, which may cause reconfiguration of the underlying brain organisation. We measured cortical thickness of more precise localization of sulco-gyral regions on patients with chronic pain due to knee osteoarthritis and healthy controls. By applying graph theory analysis, we present a preliminary morphometric signature of knee osteoarthritis pain.

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