Abstract #1893
The Role of Cerebral Oedema in the Development of Acute Mountain Sickness: A MRI Study
Ravjit Singh Sagoo 1 , Victoria Bull 2 , Helen Parsons 3 , Sarah Wayte 4 , Eddie Ng'andwe 1 , Charles Handford 5 , Mahmud Saedon 6 , Chris Koller 2 , Alex Wright 7,8 , Arthur Bradwell 7,8 , Christopher Imray 6,8 , and Charles Hutchinson 1,9
1
Department of Imaging, University Hospitals
Coventry and Warwickshire NHS Trust, Coventry, United
Kingdom,
2
Department
of Clinical Physics and Bioengineering, University
Hospitals Coventry and Warwickshire NHS Trust, Coventry,
United Kingdom,
3
Division
of Health Sciences, Warwick Medical School, University
of Warwick, Coventry, United Kingdom,
4
Department
of Medical Physics, University Hospitals Coventry and
Warwickshire NHS Trust, Coventry, United Kingdom,
5
University
Hospitals Birmingham NHS Foundation Trust, Birmingham,
United Kingdom,
6
Department
of Surgery, University Hospitals Coventry and
Warwickshire NHS Trust, Coventry, United Kingdom,
7
University
of Birmingham, Birmingham, United Kingdom,
8
Birmingham
Medical Research Expeditionary Society, Birmingham,
United Kingdom,
9
University
of Warwick, Coventry, United Kingdom
Acute mountain sickness (AMS) develops in individuals
following rapid ascent to high altitudes with low
atmospheric oxygen levels. One of the proposed theories
is that AMS may be due to an increase in intracranial
pressure as a result of cerebral oedema. Based on
changes in serial apparent diffusion coefficient (ADC)
maps over a 22-hour period of normobaric hypoxia, we
demonstrated that ADC values were significantly higher
within the corpus callosum at 11 and 22 hours compared
to baseline (p<0.01), representing oedema. This change
was independent of the presence of AMS. No other
significant changes in cerebral ADC values were
observed.
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