Abstract #1895
Occupational Manganese Exposure Levels Correlate with Brain GABA Levels
Ulrike Dydak 1,2 , Eric J Ward 3 , Ruoyun Ma 1 , Sandy Snyder 1 , Elizabeth Zauber 4 , James B Murdoch 5 , Zaiyang Long 1 , and Frank Rosenthal 1
1
School of Health Sciences, Purdue
University, West Lafayette, IN, United States,
2
Dept.
of Radiology and Imaging Sciences, Indiana University
School of Medicine, Indianapolis, IN, United States,
3
School
of Health Sciences, Purdue Universiy, West Lafayette,
IN, United States,
4
Department
of Neurology, Indiana University School of Medicine,
Indianapolis, IN, United States,
5
Toshiba
Medical Research Institute USA, Mayfield Village, OH,
United States
Thalamic GABA levels have been shown to be elevated in
metal workers occupationally exposed to manganese (Mn).
While symptoms of Mn neurotoxicity resemble those of
Parkinsons disease, the role of basal ganglia GABA is
not clear in this context. This study finds a
significant correlation between thalamic GABA levels and
individual Mn exposure levels accumulated over the past
three months in typically exposed welders, suggesting
that GABA might serve as biomarker of
recent
exposure.
Since the thalamus plays a major role in regulating
cognitive and motor function, these findings may help to
further elucidate the underlying mechanism of Mn
neurotoxicity.
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