Abstract #1896
Quantitative cerebral water content changes after CSF removal in idiopathic normal pressure hydrocephalus: a preliminary analysis using MRI at 3 T
Zaheer Abbas 1 , Kathrin Reetz 1,2 , Ana Sofia Costa 2 , Vincent Gras 1 , Shahram Mirzazade 1,2 , Johannes Schiefer 2 , Georg Neuloh 3 , Jrg Bernhard Schulz 2,4 , and N Jon Shah 1,2
1
INM-4, Research Centre Jlich GmbH, Jlich,
Germany,
2
Department
of Neurology, RWTH Aachen University, Aachen, Germany,
3
Department
of Neurosurgery, RWTH Aachen University Hospital,
Aachen, Germany,
4
Translational
Brain Medicine, Jlich Aachen Research Alliance (JARA),
Jlich and Aachen, Germany
Proton density (PD) is tightly regulated in the human
brain. Quantitative measures of PD have provided new
insights into monitoring disease progression. MRI
protocols were set up to quantitatively assess PD in
idiopathic normal pressure hydrocephalus (iNPH)
patients, before and after cerebrospinal fluid (CSF)
removal by lumbar puncture. Data were co-registered to
the MNI brain template and PD mean values for total
white matter (WM), total grey matter (GM), frontal,
parietal, occipital and temporal WM and GM were
determined. Although, no changes in GM were found,
increased water content in WM (about 3%) in iNPH
decreased after lumbar puncture.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
