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Abstract #1896

Quantitative cerebral water content changes after CSF removal in idiopathic normal pressure hydrocephalus: a preliminary analysis using MRI at 3 T

Zaheer Abbas 1 , Kathrin Reetz 1,2 , Ana Sofia Costa 2 , Vincent Gras 1 , Shahram Mirzazade 1,2 , Johannes Schiefer 2 , Georg Neuloh 3 , Jrg Bernhard Schulz 2,4 , and N Jon Shah 1,2

1 INM-4, Research Centre Jlich GmbH, Jlich, Germany, 2 Department of Neurology, RWTH Aachen University, Aachen, Germany, 3 Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany, 4 Translational Brain Medicine, Jlich Aachen Research Alliance (JARA), Jlich and Aachen, Germany

Proton density (PD) is tightly regulated in the human brain. Quantitative measures of PD have provided new insights into monitoring disease progression. MRI protocols were set up to quantitatively assess PD in idiopathic normal pressure hydrocephalus (iNPH) patients, before and after cerebrospinal fluid (CSF) removal by lumbar puncture. Data were co-registered to the MNI brain template and PD mean values for total white matter (WM), total grey matter (GM), frontal, parietal, occipital and temporal WM and GM were determined. Although, no changes in GM were found, increased water content in WM (about 3%) in iNPH decreased after lumbar puncture.

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