Abstract #1898
Apparent Fibre Density (AFD) Analysis Reveals Decreases in Axonal Density in the White Matter Pathways of Patients with Grey Matter Heterotopia
Shawna Farquharson 1,2 , David Raffelt 1 , Farnoosh Sadeghian 1 , J-Donald Tournier 1,3 , Simone Mandelstam 1,4 , Michal Schneider-Kolsky 2 , Samuel F Berkovic 5 , Ingrid Scheffer 1,5 , Graeme Jackson 1,6 , and Alan Connelly 1,5
1
The Florey Institute of Neuroscience and
Mental Health, Melbourne, Victoria, Australia,
2
Department
of Medical Imaging & Radiation Science, Monash
University, Melbourne, Victoria, Australia,
3
Deptartment
of Medicine, Austin Health, University of Melbourne,
Victoria, Australia,
4
Medical
Imaging, Royal Children's Hospital, Melbourne, Victoria,
Australia,
5
Department
of Medicine, Austin Health, University of Melbourne,
Victoria, Australia,
6
Department
of Medicine, Austin Health,University of Melbourne,
Victoria, Australia
Individuals with neuronal migration disorders such as
heterotopia often present with epilepsy that is
refractory to medical and surgical treatment. Recent
fibre tractography studies of periventricular nodular
heterotopia (PVNH) patients have reported abnormal fibre
tracks associated with regions of heterotopia. In the
present study we use Apparent Fibre Density (AFD) to
perform whole brain voxel-based analysis of DWI data
from patients with PVNH to investigate differences in
tissue microstructure. We observed a significant
decrease in AFD in many white matter tracts beyond
regions of heterotopia in PVNH patients compared to
healthy control participants.
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