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Abstract #1898

Apparent Fibre Density (AFD) Analysis Reveals Decreases in Axonal Density in the White Matter Pathways of Patients with Grey Matter Heterotopia

Shawna Farquharson 1,2 , David Raffelt 1 , Farnoosh Sadeghian 1 , J-Donald Tournier 1,3 , Simone Mandelstam 1,4 , Michal Schneider-Kolsky 2 , Samuel F Berkovic 5 , Ingrid Scheffer 1,5 , Graeme Jackson 1,6 , and Alan Connelly 1,5

1 The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia, 2 Department of Medical Imaging & Radiation Science, Monash University, Melbourne, Victoria, Australia, 3 Deptartment of Medicine, Austin Health, University of Melbourne, Victoria, Australia, 4 Medical Imaging, Royal Children's Hospital, Melbourne, Victoria, Australia, 5 Department of Medicine, Austin Health, University of Melbourne, Victoria, Australia, 6 Department of Medicine, Austin Health,University of Melbourne, Victoria, Australia

Individuals with neuronal migration disorders such as heterotopia often present with epilepsy that is refractory to medical and surgical treatment. Recent fibre tractography studies of periventricular nodular heterotopia (PVNH) patients have reported abnormal fibre tracks associated with regions of heterotopia. In the present study we use Apparent Fibre Density (AFD) to perform whole brain voxel-based analysis of DWI data from patients with PVNH to investigate differences in tissue microstructure. We observed a significant decrease in AFD in many white matter tracts beyond regions of heterotopia in PVNH patients compared to healthy control participants.

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