Abstract #1904
Decreased Apparent Fibre Density in Dravet Syndrome
David Raffelt 1 , Donna Parker 1 , Jacinta M McMahon 1 , Ingrid E Scheffer 1,2 , and Alan Connelly 1,2
1
Florey Institute of Neuroscience and Mental
Health, Melbourne, VIC, Australia,
2
Department
of Medicine, University of Melbourne, Melbourne, VIC,
Australia
Dravet syndrome is a devastating disease characterised
by the onset of infantile seizures, with myoclonic,
focal, and absence seizures developing later in life.
Childhood development is slowed resulting in
intellectual disability in most patients. Despite a
well-recognised molecular etiology, little is understood
about the pathophysiology. MRI abnormalities to date
have been relatively sparse and not reflective of the
severity of the clinical picture. We performed the first
diffusion MRI study of Dravet syndrome by a whole-brain
analysis of Apparent Fibre Density (AFD). We observed a
marked decrease in AFD in the majority of white matter
tracts compared to control participants.
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