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Abstract #1904

Decreased Apparent Fibre Density in Dravet Syndrome

David Raffelt 1 , Donna Parker 1 , Jacinta M McMahon 1 , Ingrid E Scheffer 1,2 , and Alan Connelly 1,2

1 Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia, 2 Department of Medicine, University of Melbourne, Melbourne, VIC, Australia

Dravet syndrome is a devastating disease characterised by the onset of infantile seizures, with myoclonic, focal, and absence seizures developing later in life. Childhood development is slowed resulting in intellectual disability in most patients. Despite a well-recognised molecular etiology, little is understood about the pathophysiology. MRI abnormalities to date have been relatively sparse and not reflective of the severity of the clinical picture. We performed the first diffusion MRI study of Dravet syndrome by a whole-brain analysis of Apparent Fibre Density (AFD). We observed a marked decrease in AFD in the majority of white matter tracts compared to control participants.

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