Abstract #1903
White Matter Abnormalities in Males with suppressed HIV-Infection on Combination Antiretroviral Therapy compared to Representative Controls
Tanja Su 1 , Matthan Caan 1 , Ferdinand Wit 2 , Judith Schouten 3 , Gert Geurtsen 3 , Ben Schmand 3 , Frans Vos 4 , Peter Portegies 5 , Peter Reiss 2 , and Charles Majoie 1
1
Radiology, Academic Medical Center,
Amsterdam, Netherlands,
2
Infectious
disease, Academic Medical Center, Amsterdam,
Netherlands,
3
Neurology,
Academic Medical Center, Amsterdam, Netherlands,
4
Delft
University of Technology, Delft, Netherlands,
5
Neurology,
OLVG hospital, Amsterdam, Netherlands
HIV-associated neurocognitive disorder (HAND) has been
suggested to remain common in patients with suppressed
viraemia on combination antiretroviral therapy (cART).
We used DTI tract-based spatial statistics (TBSS) to
explore the contribution of white matter microstructural
disintegration to HAND. Locally increased mean
diffusivity in callosal fibers and association fibers
were found in HIV-infected men on cART compared to
representative uninfected controls. However, an
association with cognitive impairment or impairment in
any of the individually tested domains could not be
demonstrated.
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