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Abstract #1903

White Matter Abnormalities in Males with suppressed HIV-Infection on Combination Antiretroviral Therapy compared to Representative Controls

Tanja Su 1 , Matthan Caan 1 , Ferdinand Wit 2 , Judith Schouten 3 , Gert Geurtsen 3 , Ben Schmand 3 , Frans Vos 4 , Peter Portegies 5 , Peter Reiss 2 , and Charles Majoie 1

1 Radiology, Academic Medical Center, Amsterdam, Netherlands, 2 Infectious disease, Academic Medical Center, Amsterdam, Netherlands, 3 Neurology, Academic Medical Center, Amsterdam, Netherlands, 4 Delft University of Technology, Delft, Netherlands, 5 Neurology, OLVG hospital, Amsterdam, Netherlands

HIV-associated neurocognitive disorder (HAND) has been suggested to remain common in patients with suppressed viraemia on combination antiretroviral therapy (cART). We used DTI tract-based spatial statistics (TBSS) to explore the contribution of white matter microstructural disintegration to HAND. Locally increased mean diffusivity in callosal fibers and association fibers were found in HIV-infected men on cART compared to representative uninfected controls. However, an association with cognitive impairment or impairment in any of the individually tested domains could not be demonstrated.

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