Abstract #1902
Cerebral Blood Flow Changes Related to Pain Intensity in Chronic Knee Osteoarthritis
William J Cottam 1,2 , Jennifer Dixon 1,2 , Laura Condon 1,2 , Maryam Abaei 1,2 , and Dorothee Auer 1,2
1
Radiological and Imaging Sciences, Clinical
Neurosciences, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
2
ARUK
Pain Centre, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom
In this study we aimed to characterise the central
processing of chronic knee osteoarthritis (OA) pain. We
investigated the interrelations between regional
cerebral blood flow (CBF) and the level of experienced
spontaneous OA pain severity in chronic knee OA pain
patients. Within patient analysis showed positive
correlations between spontaneous pain severity (VAS
scores) and local CBF within the anterior cingulate
cortex, left hippocampus, left amygdala, left insula,
left thalamus, left putamen, subcallosal cortex and the
brain stem. In conclusion, this study shows that ASL
imaging allows us to map spontaneous OA pain involving
known sensory and emotional pain processing areas.
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