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Abstract #1902

Cerebral Blood Flow Changes Related to Pain Intensity in Chronic Knee Osteoarthritis

William J Cottam 1,2 , Jennifer Dixon 1,2 , Laura Condon 1,2 , Maryam Abaei 1,2 , and Dorothee Auer 1,2

1 Radiological and Imaging Sciences, Clinical Neurosciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 ARUK Pain Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

In this study we aimed to characterise the central processing of chronic knee osteoarthritis (OA) pain. We investigated the interrelations between regional cerebral blood flow (CBF) and the level of experienced spontaneous OA pain severity in chronic knee OA pain patients. Within patient analysis showed positive correlations between spontaneous pain severity (VAS scores) and local CBF within the anterior cingulate cortex, left hippocampus, left amygdala, left insula, left thalamus, left putamen, subcallosal cortex and the brain stem. In conclusion, this study shows that ASL imaging allows us to map spontaneous OA pain involving known sensory and emotional pain processing areas.

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