Abstract #1901
Microstructural abnormalities related to the chronification of osteoarthritic pain: a DTI study
Diane Reckziegel 1,2 , Jennifer Dixon 1,2 , and Dorothee P. Auer 1,2
1
Radiological Sciences, Division of Clinical
Neurosciences, University of Nottingham, Nottingham,
United Kingdom,
2
Arthritis
Research UK Pain Centre, Nottingham, United Kingdom
DTI was used to investigate potential brain
microstructural disruptions underlying any adaptive or
predisposing changes to the networks in the brain in
response to chronic knee pain due to osteoarthritis
(OA). TBSS and ROI-based analysis revealed an increase
in thalamic MD as pain duration increases, and a
tendency for association between more neuropathic-like
symptoms and MD in an area involving the insula and ACC.
Our findings suggest that microstructural abnormalities
in OA pain, a primary nociceptive condition, are a
feature of pain chronification. They seem to develop
after several years of persistent pain probably
preferentially in patients with more neuropathic-like
symptoms.
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