Abstract #1900
Evidence of a topographical and inflammatory brain response in Human T Lymphotropic Virus type-1-associated myelopathy (HAM)
Courtney A Bishop 1,2 , Qi Guo 3 , Rahul Dimber 1 , Rexford D Newbould 1,2 , Roger N Gunn 1,2 , Eugenii A Rabiner 1,3 , and Graham P Taylor 4
1
Imanova Centre for Imaging Sciences, London,
United Kingdom,
2
Department
of Medicine, Imperial College London, London, United
Kingdom,
3
King's
College London, London, United Kingdom,
4
St
Mary's Hospital, Imperial College Healthcare NHS Trust,
London, United Kingdom
HTLV1-associated myelopathy (HAM) is a chronic,
debilitating neuro-inflammatory disease that may be
associated with neuro-cognitive defects in spite of
being a peripheral infection. In this study, we used VBM
and DTI to attempt to differentiate six HAM patients
(with high viral load but varying disease burden) from
healthy controls, in order to probe CNS changes before
the development of cognitive defects. Both VBM and DTI
analysis identified the thalamus as correlated to
disease burden, which was reinforced by [11C]PBR28 PET
identifying the thalamus as an area of inflammation in
HAM patients.
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