Abstract #1910
Diffusion tensor imaging in bulbar and limb-onset amyotrophic lateral sclerosis
Arturo Cardenas-Blanco 1 , Judith Machts 2 , Julio Acosta-Cabronero 1 , Joern Kaufmann 2 , Susanne Abdulla 3 , Katja Kollewe 3 , Susanne Petri 3 , Reinhard Dengler 3 , Stefan Vielhaber 2 , and Peter Nestor 1
1
Brain Plasticity & Neurodegeneration, German
Center for Neurodegenerative Diseases (DZNE), Magdeburg,
Saxony-Anhalt, Germany,
2
Neurology,
Magdeburg medical school, Magdeburg, Germany,
3
Neurology,
Hannover medical school, Hannover, Germany
Bulbar onset amyotrophic lateral sclerosis (ALS-B) has a
worse prognosis that limb onset (ALS-L). This could
reflect either that ALS-B targets muscles more critical
for survival or because it is biologically more
aggressive. The purpose of this study was to compare
patterns of neuro-degeneration between ALS-B and ALS-L
patients carefully matching age, sex, cognitive
impairment and motor dysfunction using DTI. The results
indicated that both groups had similar distribution of
change (corticospinal tracts) although ALS-B had more
severe white matter tract degeneration than ALS-L. This
suggests that, when matched for clinical markers of
severity, ALS-B is a more aggressive variant.
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