Abstract #1911
Single subject VBM analysis
Joao M. S. Pereira 1 , Julio Acosta-Cabronero 2 , Peter J. Nestor 2 , Guy B. Williams 3 , and Miguel Castelo-Branco 4
1
Laboratory of Biostatistics, IBILI - Faculty
of Medicine, University of Coimbra, Coimbra, Portugal,
2
German
Centre for Neurodegenerative Diseases (DZNE), Magdeburg,
Germany,
3
Department
of Clinical Neurosciences, University of Cambridge,
Cambridge, United Kingdom,
4
Visual
Sciences Laboratory, IBILI - Faculty of Medicine,
University of Coimbra, Coimbra, Portugal
Voxel based morphometry (VBM) is a common brain imaging
tool used in research to detect differences in the
volume of brain tissues between groups. Its application
to a clinical setting has been hampered by its inability
to assess single subjects. This work presents a proof of
concept of single subject VBM, using a nonlinear
registration algorithm to simulate normal anatomical
variability and thus generate a sample of subjects out
of a single scan.
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