Abstract #1915
Investigating the long-term effects of systemic chemotherapy on brain white matter using multi-shell diffusion MRI and myelin water imaging
Thibo Billiet 1,2 , Sabine Deprez 1,2 , Burkhard Maedler 3 , Ronald Peeters 1,2 , Hui Zhang 4 , Alexander Leemans 5 , Thijs Dhollander 6 , Daan Christiaens 6 , Frederic Amant 7 , Ann Smeets 7 , Bea Van den Bergh 8 , Mathieu Vandenbulcke 9 , Eric Legius 10 , Stefan Sunaert 1,2 , and Louise Emsell 1,2
1
Translational MRI, Imaging & Pathology, KU
Leuven & Radiology, University Hospitals Leuven, Leuven,
Belgium,
2
Medical
Imaging Research Center, Leuven, Belgium,
3
Stereotaxis
and MR-based Intervention, Department of Neurosurgery,
Bonn University Hospital, Bonn, Germany,
4
Computer
Science, University College London, London, United
Kingdom,
5
University
Medical Center, Utrecht, Netherlands,
6
ESAT-PSI
Processing Speech and Images, KU Leuven, Leuven,
Belgium,
7
Leuven
Cancer Institute (LKI), Multidisciplinary Breast Cancer
Unit, KU Leuven & University Hospitals Leuven, Belgium,
8
Developmental
Psychology, Tilburg University, Tilburg, Netherlands,
9
Psychiatry,
KU Leuven & University Hospitals Leuven, Leuven,
Belgium,
10
Human
Genetics, KU Leuven & University Hospitals Leuven,
Leuven, Belgium
Systemic chemotherapy as a treatment against breast
cancer patients is known to induce cognitive deficits,
related with alterations in diffusion tensor imaging
(DTI) measures of the brain's white matter. Using
advanced diffusion techiques (DTI, DKI, NODDI) and
multicomponent T2 relaxation, the long-term effects of
this chemotherapy treatment are assessed.
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