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Abstract #1915

Investigating the long-term effects of systemic chemotherapy on brain white matter using multi-shell diffusion MRI and myelin water imaging

Thibo Billiet 1,2 , Sabine Deprez 1,2 , Burkhard Maedler 3 , Ronald Peeters 1,2 , Hui Zhang 4 , Alexander Leemans 5 , Thijs Dhollander 6 , Daan Christiaens 6 , Frederic Amant 7 , Ann Smeets 7 , Bea Van den Bergh 8 , Mathieu Vandenbulcke 9 , Eric Legius 10 , Stefan Sunaert 1,2 , and Louise Emsell 1,2

1 Translational MRI, Imaging & Pathology, KU Leuven & Radiology, University Hospitals Leuven, Leuven, Belgium, 2 Medical Imaging Research Center, Leuven, Belgium, 3 Stereotaxis and MR-based Intervention, Department of Neurosurgery, Bonn University Hospital, Bonn, Germany, 4 Computer Science, University College London, London, United Kingdom, 5 University Medical Center, Utrecht, Netherlands, 6 ESAT-PSI Processing Speech and Images, KU Leuven, Leuven, Belgium, 7 Leuven Cancer Institute (LKI), Multidisciplinary Breast Cancer Unit, KU Leuven & University Hospitals Leuven, Belgium, 8 Developmental Psychology, Tilburg University, Tilburg, Netherlands, 9 Psychiatry, KU Leuven & University Hospitals Leuven, Leuven, Belgium, 10 Human Genetics, KU Leuven & University Hospitals Leuven, Leuven, Belgium

Systemic chemotherapy as a treatment against breast cancer patients is known to induce cognitive deficits, related with alterations in diffusion tensor imaging (DTI) measures of the brain's white matter. Using advanced diffusion techiques (DTI, DKI, NODDI) and multicomponent T2 relaxation, the long-term effects of this chemotherapy treatment are assessed.

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