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Abstract #1914

An investigation of functional connectivity in the cognitive control network in Prodromal Huntington's Disease

Katherine A Koenig 1 , Mark J Lowe 1 , Jian Lin 1 , Deborah L Harrington 2 , Ken E Sakaie 1 , Jane S Paulsen 3 , and Stephen M Rao 4

1 Imaging Sciences, The Cleveland Clinic, Cleveland, OH, United States, 2 Research, Neurology, and Radiology Services, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, 3 Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, Iowa, United States, 4 Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States

Activation on a motor task was used to seed a resting state connectivity analysis in the left primary motor cortex (M1) in 48 participants in the prodromal stages of Huntingtons disease (preHD) and 16 gene-negative participants. Bilateral anterior cerebellar lobes and bilateral middle temporal gyri showed a relationship between strength of connectivity to left M1 and time-to-onset in preHD. These findings suggest that connectivity strength is impacted by disease process prior to onset of symptoms in HD.

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