Abstract #1924
Voxel-based morphometery to detect the effect of APOE on brain grey matter changes in Parkinsons Disease
David Neil Manners 1 , Emil Malucelli 2 , Giuseppe Nicoletti 3 , Claudia Testa 1 , Caterina Tonon 1 , Aldo Quattrone 3 , and Raffaele Lodi 1
1
Dept of Biomedical and Neuromotor Sciences,
University of Bologna, Bologna, Emilia Romagna, Italy,
2
Dept
of Pharmacy and Biotechnology, University of Bologna,
Bologna, Emilia Romagna, Italy,
3
National
Research Council Neuroimaging Research Unit, University
Magna Graecia, Catanzaro, Calabria, Italy
A voxel-based morphometry analysis was conducted on
isotropic T1-weighted brain image volumes, acquired at
1.5 T, to determine whether variations in the APOE
allele, known as a risk factor in disorders such as
Alzheimers disease, are also associated with grey
matter degenerative changes in patients with Parkinsons
disease (PD), with or without dementia. Despite a small
increase in whole brain CSF in patients with the ε4
allele, after accounting for age, brain size and
dementia, no localized grey matter changes were
detected. Variations in the APOE allele are not
associated with grey matter degenerative changes in the
PD patients studied.
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