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Abstract #1928

In vivo imaging of Tau pathology using Multi-Parametric Quantitative MRI

Jack A Wells 1 , James M O'Callaghan 1 , Holly E Holmes 1 , Nicholas M Powell 1 , Bernard Siow 1 , F Torrealdea 2 , Marilena Rega 2 , Ozama Ismail 1 , Simon Walker-Samuel 1 , Xavier Golay 2 , Simon Richardson 1 , Adam J Schwarz 3 , Michael J O'Neil 4 , Emily C Collins 3 , Niall Colgan 1 , and Mark F Lythgoe 1

1 Centre for Advanced Biomedical Imaging, UCL, London, London, United Kingdom, 2 Institute of Neurology, UCL, London, United Kingdom, 3 Lilly Corporate Centre, Eli Lilly & Co. Ltd, Indianapolis, United States, 4 Eli Lilly & Co. Ltd Erl Wood Manor, Windlesham, Surrey, United Kingdom

In this study, we target diverse and specific components of tau pathology by applying multi-parametric MRI to the rTg4510 model of Alzheimers disease. We investigate how elevated tau expression affects: i) cerebral blood flow using arterial spin labelling ii) chemical exchange saturation transfer iii) brain glucose uptake using gluco-CEST iv) diffusion tensor imaging and v) brain atrophy using tensor based morphometry. Each technique can unambiguously discriminate tau pathology from healthy control subjects in selective white and grey matter regions, providing a platform for the longitudinal assessment of experimental treatments using non-invasive imaging techniques.

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