Regional Transverse Relaxation Alterations in the APP/PS1/Tau Alzheimers Disease Transgenic Mouse Model Following Diet Induced Iron Loading
Mark David Meadowcroft 1,2 , Douglas G Peters 1 , Carson Purnell 2 , James R Connor 1 , and Qing X Yang 1,2
Neurosurgery, The Pennsylvania State
University - College of Medicine, Hershey, PA, United
The Pennsylvania State University - College of Medicine,
Hershey, PA, United States
The role of iron in the formation of amyloid-beta
plaques and neurofibrillary-tangles in not well
understood. Our research has shown that the APP/PS1
transgenic mouse model produces plaques in a light iron
environment compared to Alzheimers disease.
Furthermore, transgenic model plaques exhibit dissimilar
plaque morphology, inflammatory response, and have less
focal iron. The goal of this study is to recapitulate
the Alzheimers neuronal milieu through diet induced
iron over-loading with a novel lipophilic compound and
evaluate the role of iron on Alzheimers disease
pathology. The results show longitudinal changes in
regional transverse relaxation indicative of iron
loading and plaque progression.
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